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vicissitude
1 a: the quality or state of being changeable : mutability b: natural change or mutation visible in nature or in human affairs2 a: a favorable or unfavorable event or situation that occurs by chance : a fluctuation of state or condition <the vicissitudes of daily life> b: a difficulty or hardship attendant on a way of life, a career, or a course of action and usually beyond one's control c: alternating change : succession
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